Human BMP4 mRNA Encapsulated in Lipid Nanoparticle for Bone and Articular Cartilage Repair in Aged Mice.

J Funct Biomater · 2026 · PMC13301014 · PMID 42346664

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hedged sentences

0.0564

closest p · 1.1× alpha

0.0754

boldest claim

The sentences

nearly statistically significantp = 0.0564so close (0.05 < p ≤ 0.1)

A slight increase was observed in hBMP4 protein level at 4 h post-transfection ( Figure 2 B), with the 4 μg group having a nearly statistically significant increase ( p = 0.0564).

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an increasing trendp = 0.0754so close (0.05 < p ≤ 0.1)

However, at 24 h post-transfection, BMP4 secretion showed an increasing trend in the 1 μg dose ( p = 0.0754) ( Figure 3 C), while there was a significant increase in BMP4 secretion in the 2 μg dose ( p = 0.0347) ( Figure 3 C).

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a decreasing trendno p-value reported

Furthermore, when we examined P16 and P21 expression, we found that P16 mRNA expression was significantly decreased at the 1 μg and 2 μg doses and showed a decreasing trend in the 4 μg dose and hBMP4 protein groups ( Figure 2 I).

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showed a trendno p-value reported

hBMP4 mRNA/LNP treatment showed a trend of pain alleviation and did not change serum hyaluronic acid levels.

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