Is Combined Tranexamic Acid Administration Superior to Single-Route Protocols in Primary Total Knee Arthroplasty? A Prospective Cohort Study

J Clin Med · 2026 · PMC13301024

Europe PMC

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failed to reach statistical significanceno p-value reported

Conversely, intra-articular (IA) administration failed to reach statistical significance as an independent predictor, suggesting that IA administration alone was not significantly associated with reduced total blood loss in this analysis.

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did not reach statistical significanceno p-value reported

Furthermore, although transfusion rates did not reach statistical significance, the absolute values showed a tendency in favor of systemic protocols without reaching statistical significance. 4.5.

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