Sharp-Wave EEG Activity and Cytomegalovirus Exposure in Schizophrenia Spectrum Disorders: A Neuroimmune Perspective.

Conversely, the lower occurrence of such paroxysmal EEG patterns in the CMV-seropositive cohort, alongside the lack of differences in the SCoRS global rating or total score, might tentatively reflect a subtle, chronic viral-induced exhaustion of these plastic compensatory mechanisms—a pattern potentially consistent with frontally mediated network mechanisms [ 62 , 63 ] that manifests nominally as a slight trend toward disorganization.

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Following strict multiple comparisons correction, these findings were attenuated to strong, near-significant nominal trends ( p BH = 0.067 and p BH = 0.060, respectively).

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While this difference achieved high nominal significance prior to multiple comparisons correction (Yates-corrected p = 0.003), it retained only a marginal significance after Benjamini–Hochberg adjustment ( p BH = 0.087).

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Within background rhythm morphology, alpha activity with sharply contoured morphology demonstrated a strong trend toward an association with CMV serological status, being observed more frequently among CMV-seronegative patients (20.00%) compared with CMV-seropositive patients (2.94%).

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