Effect of Failed Debridement, Antibiotics, and Implant Retention on Subsequent Two-Stage Reimplantation for Periprosthetic Joint Infection Following Total Knee Arthroplasty: A Retrospective Cohort Study

J Clin Med · 2026 · PMC13302502

Europe PMC

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did not reach statistical significancep = 0.053so close (0.05 < p ≤ 0.1)

showed a trendno p-value reported

Prior DAIR showed a trend toward lower failure rates but did not reach statistical significance (HR = 0.043, 95% CI: 0.002–1.039, p = 0.053).

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a nonsignificant trendno p-value reported

These findings are consistent with a recent systematic review and meta-analysis suggesting that prior failed DAIR does not uniformly compromise subsequent two-stage revision success, although a nonsignificant trend toward lower success and substantial between-study heterogeneity were noted.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.