Although age ≥65 years (HR 1.52, 95% CI 0.93–2.48; P =.09) and pathological stage T4N0 (HR 1.65, 95% CI 0.98–2.77; P =.06) showed a trend toward worse outcomes, these associations did not reach statistical significance after adjustment for confounding factors ( Table 4 ).
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Comparative overall survival in T4N0 and T2-3N1 non-metastatic colon cancer: a retrospective cohort study.
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The borderline significance after adjustment suggests that the effect on DFS may be partially mediated by interactions with other clinical-pathological factors and treatment patterns.