Evolution of blood biomarkers reflective of brain tissue damage and inflammation in the perioperative course of intracerebral haemorrhage evacuation in a phase II proof-of-concept trial.

BMJ Open · 2026 · PMC13311760 · PMID 42350006

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hedged sentences

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

showed a trendp=0.09so close (0.05 < p ≤ 0.1)

At BL, GFAP showed a trend for a correlation with haematoma volume (ρ=0.58, p=0.09).

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a strong trendno p-value reported

Biomarker associations with haematoma volume and satisfactory haematoma evacuation NfL levels did not correlate with haematoma volumes at BL (ρ=0.41, p=0.25) but showed a strong trend to be lower at 72 hours and 1 week in patients with satisfactory versus unsuccessful haematoma evacuation: 72 hours: 64.6 (55.2–139.9) versus 259.2 (179.2–268.4) pg/mL, p=0.067; at 1 week: 228.6 (115.4–249.3) vs 484.6 (392.4–627.7) pg/mL, p=0.067 ( online supplemental figure 4 ).

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