Perioperative ctDNA as a prognostic biomarker in endometrial cancer - the CODEC study.

Transl Oncol · 2026 · PMC13316190 · PMID 42330843

Europe PMC DOI

hedged sentences

0.0620

closest p · 1.2× alpha

0.0620

boldest claim

The sentences

did not reach statistical significancep = 0.062so close (0.05 < p ≤ 0.1)

However, the difference in recurrence-free survival did not reach statistical significance (HR 4.32, p = 0.062). ctDNA positivity post EC surgery predicts relapse As seen in other cancers [ 27 , 28 , 41 ], detection of ctDNA following surgery indicates MRD and therefore has strong biological rationale as a prognostic biomarker.

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showed a trendno p-value reported

Similarly, while preoperative ctDNA showed a trend toward increased relapse risk, consistent with prior EC studies [ 47 ], this did not reach statistical significance.

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