Prolonged low-dose tPA ameliorates coagulopathy and organ injury in an LPS-induced rat DIC model.

Int J Hematol · 2026 · PMC13319167 · PMID 41801558

Europe PMC DOI

hedged sentences

0.0840

closest p · 1.7× alpha

0.0840

boldest claim

The sentences

did not reach statistical significanceP = 0.084so close (0.05 < p ≤ 0.1)

showed a trendP = 0.084so close (0.05 < p ≤ 0.1)

Although the difference did not reach statistical significance after multiple comparison adjustment, the PROP-tPA/8 h group showed a trend toward lower IL-6 levels compared with the LPS group (adjusted P = 0.084).

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highly significantno p-value reported

Consequently, the similarity in results obtained with therapeutic tPA administration was deemed highly significant.

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a decreasing trendno p-value reported

an increasing trendno p-value reported

Regarding mortality, an increasing trend was evident in the PROP-tPA/15 min group compared to LPS group, while a decreasing trend was seen in the PROP-tPA/4 h and PROP-tPA/8 h groups, although no significant differences were evident in either group compared to LPS group (Fig. 2 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.