Impact of Respiratory Effort Parameters on Clinical Outcomes in Respiratory Failure Patients (Effort-I): A Prospective Observational Study.

Although the difference in 28-day VFDs between the calculated Pmus 5–10 cmH 2 O and >10 cmH 2 O groups did not reach statistical significance, the numerical difference was substantial and may reflect limited power in the smaller high-Pmus subgroup rather than the absence of a clinically relevant effect.

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In our cohort, the high-P 0.1 subgroup showed a trend toward higher lactate and SOFA scores than the reference group, and RASS correlated with inspiratory effort parameters, particularly calculated P mus .

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