<i>CDKN2A</i> mRNA Over-expression Is Associated With CD8+ T Cell Exclusion and IDO1-Mediated Adaptive Immune Resistance in Gastric Adenocarcinoma.

Direct correlation analysis further revealed that IDO1 expression maintained a strong, highly significant positive correlation with CD8+ T cell infiltration (R=0.64, p =2.2×10 -16 ) ( Figure 3 ).

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While the OE group exhibited an early trend toward inferior overall survival, particularly between 24 and 48 months, the differences across the three groups did not reach statistical significance in the whole TCGA-STAD transcriptomic cohort ( p =0.3).

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Notably, the Loss cohort showed a trend toward superior survival outcomes in the first five years of follow-up compared to both the WT and OE groups ( Figure 5 ).

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