Alcohol drinking sex-dependently regulates interleukin-1 pro-inflammatory signaling in the prefrontal cortex of mice and rhesus macaques.

Brain Behav Immun · 2026 · PMC13322405 · PMID 41833757

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hedged sentences

0.0510

closest p · 1.0× alpha

0.0510

boldest claim

The sentences

approached significancep = 0.051so close (0.05 < p ≤ 0.1)

The IL-1β-induced sIPSC amplitude of EtOH Drinker/IL-1β (in EtOH) group also approached significance, suggesting enhanced GABA A receptor function [ t (9) = 2.26, p = 0.051; ( Fig. 6J )].

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showed a trendno p-value reported

Unexpectedly, within this Male Alcohol Drinker group, Il1rap v2 /total Il1rap values showed a trend towards a positive correlation with Barnes maze retention errors ( Fig. 4C ).

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