For the 3 tandem repeat immunogen with N-terminal PADRE (PADRE-LuS-3T) the responses were significantly higher against the major repeat probe (NANP9) and showed a trend toward higher responses against PfCSP and NPDP19, but these differences were not significant (Fig. 3b , comparing groups 6 and 7 at week 6).
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Protective immunity against malaria by a nanoparticle CIS43-based junctional vaccine alone or in combination with R21.
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However, these differences did not reach statistical significance.