The C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair.

EMBO J · 2026 · PMC13324726 · PMID 42215790

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

Single knockouts showed a trend toward reduced ChAT-positive neurons, though this did not reach statistical significance. dKO mice exhibited significant reductions in NeuN-positive and ChAT-positive neurons (Fig.

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