Radiation-associated bioprosthetic valve dysfunction: an initial case-control analysis.

The gradient measured within the first 12 months following RT [median 10 mm Hg (IQR, 6–14)] also differed from the post-implantation (median difference 2 mm Hg) and pre RT baselines (median difference 2 mm Hg), but failed to reach statistical significance ( P -value = 0.08).

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In comparison to matched controls, we found a significant trend towards increasing transvalvular gradients over the subsequent 24 months, whereas no such trend was observed in controls over an equivalent period.

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