Concurrent Chemoradiotherapy Plus Immunotherapy Versus Concurrent Chemoradiotherapy in Locally Advanced Cervical Cancer: A Randomized, Single-Center, Phase II Trial of Early Tumor Regression and Pro-Inflammatory Tumor Microenvironment Remodeling.

At a 10% significance level, the CICRT group exhibited a numerical trend toward a greater reduction in residual tumor volume compared to the CCRT group (residual tumor volume 3.0% vs. 7.4%; p = 0.080, 95% confidence interval [CI]: −9.3%–0.6%, η 2 = 0.180); this met the pre‐specified threshold, although it did not reach the conventional 0.05 level.

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In the CICRT group, a consistent decrease in the proportion of malignant cells was observed across all three pairs of samples at the on‐treatment timepoint, although this did not reach statistical significance (Figure 1G ).

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Of note, within the Malig1 subcluster, the CICRT group showed a trend toward upregulation of various cytokines and chemokines, including IL1B, IL12A, CCL2, CCL3, CCL20, CXCL1, CXCL2, CXCL3 , and CXCL8 compared to the CCRT group (Figure 2F ).

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