ENPP3 CAR T cells combined with CD206 modulation suppress adrenocortical carcinoma.

Across pediatric cancers, ACCs expressed the highest levels of ENPP3 ( figure 2F ), and these showed a trend towards worse survival ( figure 2G ).

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By Day 28, treatment with ENPP3 CAR induced suppression of tumor growth with a strong trend toward smaller weights compared with mock-treated controls ( figure 3G,H ).

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