c-MET Overexpression Drives AKT Activation, and Combined Inhibition Synergistically Enhances Therapeutic Sensitivity in Non-Small-Cell Lung Cancer.

Cells · 2026 · PMC13360048 · PMID 42439632

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showed a trendno p-value reported

c-MET overexpression was significantly associated with increased p-AKT expression and showed a trend toward poorer overall survival in the tissue microarray cohort, while analysis of the TCGA LUAD dataset confirmed a significant association with reduced survival (log-rank p = 0.0223; HR = 1.234, 95% CI: 1.029–1.480).

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did not reach statistical significanceno p-value reported

In our study, c-MET overexpression was associated with a trend toward poorer overall survival in the TMA cohort, although this did not reach statistical significance.

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