Genetic Susceptibility to Diabetic Retinopathy in the Thrace Region: Role of IL-18 (-607 C/A, -137 G/C) and IL-8 (-251 A/T) Variations.

J Clin Med · 2026 · PMC13363530 · PMID 42452667

Europe PMC DOI

hedged sentences

0.1650

closest p · 3.3× alpha

0.1650

boldest claim

The sentences

failed to reach statistical significancep = 0.165not close (p > 0.1)

Although the CA-GC combination was initially significant in our haplotype analysis (OR = 1.883, p = 0.044), it failed to reach statistical significance when the Bonferroni-corrected alpha threshold was applied (AOR = 1.45, adjusted p = 0.165).

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did not reach statistical significanceno p-value reported

However, when we applied a more rigorous multivariate model that was adjusted for systemic confounders, such as hypertension, CAD, and family history of diabetes, and enforced a conservative Bonferroni threshold of α = 0.005, this association was attenuated and did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.