Single-cell spatial transcriptomics of formalin-fixed, paraffin-embedded biopsies reveals colitis-associated cell networks.

J Clin Invest · 2026 · PMC13367960 · PMID 42262875

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did not reach statistical significanceno p-value reported

In contrast, the GALT-B-DC-S4 fibroblast signature was validated in Datasets 1 and 3 but did not reach statistical significance in the external dataset, again suggesting potential heterogeneity among VDZ nonresponders.

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showed a trendno p-value reported

UC PRE biopsies showed a trend ( P value 0.07) toward increased z scores for IAFs and monocytes, consistent with the increased abundance and proximity of IAFs and monocytes in colitis.

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