Histone H3K27 demethylation drives Crohn's disease inflammation: GSK-J4 as a potential epigenetic therapy.

Clin Epigenetics · 2026 · PMC13371444 · PMID 42169165

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did not reach statistical significanceno p-value reported

Although IL-10 mRNA showed an upward trend in LPS-stimulated macrophages, followed by a return to baseline in LPS + GSK-J4-treated cells, this did not reach statistical significance (Fig. 5 G and H).

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showed a trendno p-value reported

KDM6A mRNA levels showed a trend towards a baseline following LPS + GSK-J4 treatment, while KDM6B mRNA levels were significantly reduced compared to LPS treatment ( p < 0.05) (Fig. 4 K and L).

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