Prolonged systemic inflammation worsens impairments to astrocyte Ca<sup>2+</sup> and functional hyperemia in Alzheimer's disease.

In AD mice, we observed ∼15% to 40% higher frequencies of Ca 2+ spikes compared to age‐matched WT littermates, yet the difference did not reach statistical significance (Figure 1B,C , left, p = 0.067 soma).

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Strikingly, 14 days of LPS injection yielded reduced A β 1 − 42 load in AD mouse brain, showing statistical significance in cortex and a strong trend in the hippocampus (Figure S8D ).

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