UCP2 Identifies Immunosuppressive Tumor-Associated Macrophages and Is Associated with Predicted Immunotherapy Resistance in Glioma.

The UCP2–CD68 association remained highly significant after adjustment (partial ρ = 0.524, p = 1.80 × 10 − 48 ), confirming that the relationship between UCP2 expression and macrophage infiltration is not a spurious consequence of tumour purity variation ( Supplementary Fig.

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PKM2 showed a weak but statistically significant positive correlation ( ρ = 0.090, p .adj = 0.023), whereas SLC2A1 (GLUT1) did not reach statistical significance ( ρ = 0.055, p .adj = 0.157; Supplementary Fig.

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Given the exploratory nature of this analysis, cell types with raw p < 0.05 were considered as nominally significant. 2.7.2.

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