Intensified multifactorial intervention leads to long-term benefit on kidney outcomes in advanced diabetic kidney disease: A 10-year follow-up of the DNETT-Japan trial.

Following the 5‐year intervention, the IT group showed a trend toward a relative reduction in the risk of the composite kidney outcome, defined as a doubling of serum creatinine, end‐stage kidney disease, or death from any cause, although the difference did not reach statistical significance. 7 Notably, previous studies have suggested that the benefits of

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Following the 5‐year intervention, the IT group showed a trend toward a relative reduction in the risk of the composite kidney outcome, defined as a doubling of serum creatinine, end‐stage kidney disease, or death from any cause, although the difference did not reach statistical significance. 7 Notably, previous studies have suggested that the benefits of intensive interventions may persist or even become more apparent over time during post‐trial follow‐up. 8 , 9 , 10 Therefore, we conducted an additional 5‐year post‐intervention observational follow‐up, during which no structured intervention was applied, and routine care in accordance with clinical guidelines was provided by each study site.

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