The NLRP3 Inflammasome Increases Pulmonary Vascular Remodeling in Experimental Pulmonary Arterial Hypertension.

Pulm Circ · 2026 · PMC13404779 · PMID 42516686

Europe PMC DOI

hedged sentences

0.0531

closest p · 1.1× alpha

0.0531

boldest claim

The sentences

almost reached statistical significancep = 0.0531so close (0.05 < p ≤ 0.1)

a strong trendp = 0.0531so close (0.05 < p ≤ 0.1)

As expected, cleaved IL‐1β and IL‐18 showed a strong trend towards a decrease that almost reached statistical significance ( p = 0.0531; Figure 2A,B,D,F ).

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just failing to reach statistical significanceno p-value reported

We did, however, observe that MCC950 decreased active IL‐1β and IL‐18 in rat lung tissue, only just failing to reach statistical significance in this small sample study, suggesting that the decrease in pulmonary vascular remodeling likely occurred downstream of these two interleukins.

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