Evaluation of Serum HIF-1α as a Hypoxia-Related Biomarker in Patients with Malignant Salivary Gland Neoplasms.

Biomedicines · 2026 · PMC13406568 · PMID 42512083

Europe PMC DOI

hedged sentences

0.0640

closest p · 1.3× alpha

0.0640

boldest claim

The sentences

a strong trendp = 0.064so close (0.05 < p ≤ 0.1)

Although this difference did not reach statistical significance, a strong trend toward higher HIF-1α concentrations in more advanced disease was observed (Mann–Whitney U test, U = 53.0, p = 0.064).

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near-significantp = 0.064so close (0.05 < p ≤ 0.1)

In particular, the near-significant association observed for tumor stage ( p = 0.064) warrants further investigation in larger cohorts. 4.

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