Barely Significant
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Impact of Adding Immune Checkpoint Inhibitors to Neoadjuvant Chemotherapy on pCR and Tumor Downstaging in Resectable Gastric Cancer: A Meta-Analysis.

Cancers (Basel) · 2026 · PMC13406764 · PMID 42512335

Europe PMCDOI
2
hedged sentences
0.0505
closest p · 1.0× alpha
0.0505
boldest claim

The sentences

showed a trendp = 0.0505so close (0.05 < p ≤ 0.1)
The pooled analysis showed a trend toward improved OS with chemo-immunotherapy (pooled HR 0.78, 95% CI 0.61–1.00; p = 0.0505), although the result missed conventional statistical significance and moderate heterogeneity was observed (I 2 = 50.2%) ( Supplementary Table S1 ).

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a favorable trendno p-value reported
did not reach statistical significanceno p-value reported
A favorable trend toward nodal downstaging was observed (ypN0–1 OR 1.57; ypN2–3 OR 0.60), although these differences did not reach statistical significance.

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