Epigenetic Patterns in Musculoskeletal Disease: Methylation of <i>DKK1</i>, <i>RHOJ</i>, and <i>SOX6</i> Genes in Osteoarthritis and Osteoporosis.

However, the non-parametric Kruskal–Wallis test, applied for the comparison of all three groups, identified a highly significant overall difference (χ 2 = 13.56, df = 2, p = 0.001136).

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In summary, while methylation at the CPG1 site of DKK1 gene did not distinguish the patient cohorts from the healthy controls, it revealed a nominally significant epigenetic discrepancy. between the two clinical phenotypes, with the comorbid osteoporosis and osteoarthritis group exhibiting elevated methylation relative to the group with OA alone.

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Similarly, the comparison between the two patient groups (OP+OA versus OA without OP) failed to reach statistical significance after correction (p adj = 0.065).

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