Decompressive hemicraniectomy as a salvage therapy in the Neuro-ICU: a meta-analysis of neurologic outcomes for malignant middle cerebral artery infarction.

Front Med (Lausanne) · 2026 · PMC13407790 · PMID 42523922

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

showed a trendp = 0.06so close (0.05 < p ≤ 0.1)

The overall pooled estimate across both time points showed a trend toward improvement that did not reach statistical significance (mean difference: 21.27, 95% CI: −0.96 to 43.50, p = 0.06), with substantial heterogeneity observed ( I 2 = 80%, p = 0.03).

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