The genetics of fibromyalgia and its relationships to psychiatric and medical traits.

Nat Commun · 2026 · PMC13415558 · PMID 42521668

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close-to-significantno p-value reported

An intronic variant of POLR1C – a gene that is associated with Treacher Collins Syndrome, sensorineural hearing loss 22 and systolic BP 44 – POLR1C *rs186798404 was the only SNP that had a significant effect in the AFR meta-analysis, though it may be a false positive (there are no significant or close-to-significant high LD SNPs).

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nominally significantno p-value reported

We therefore tested the genetic correlation between the UKBB phenotypes and their closest equivalents in AoU (self-report in UKBB vs self-report in AoU, and stringent ICD-10 in UKBB vs stringent ICD-10 in AoU) and found a nominally significant effect of r g = 0.77 between the self-report traits, and a significant effect for the stringent ICD-10 traits, with r g = 1.07 (Suppl.

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