Barely Significant
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Prognostic value of monitoring tumour markers CA 15-3 and CEA during fulvestrant treatment.

BMC Cancer · 2006 · PMC1435763 · PMID 16563172

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This trend became stronger over time, but still failed to reach statistical significance after 6 months of treatment.

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Tumour marker levels in patients experiencing a PR In the seven patients experiencing a PR an increase in CA 15-3 levels was observed over the first 4 months of treatment (Table 2 ); this did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.