Logged fasting insulin 2 levels were significantly lower in the T allele groups and there was also a strong trend per T allele of reduction in HOMA2b measures, suggesting impaired beta-cell function (96% in TT versus 113% in CC group, regression p = 0.001).
Effect of TCF7L2 in the general elderly population sample In the general elderly population sample, there was a significant trend toward higher fasting glucose levels with increasing number of T alleles (mean fasting glucose 5.31 mmol/L in the TT group, 5.19 mmol/L in the CT group, and 5.08 mmol/L in the CC group; age and sex adjusted per allele regression model p = 0.028) (Table 2 ).