Systematic association mapping identifies NELL1 as a novel IBD disease gene.

PLoS One · 2007 · PMC1933598 · PMID 17684544

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did not reach statistical significanceno p-value reported

Interestingly, haplotype A-tagging SNP e26 in the DLG5 gene was replicated (over-transmission of common allele T, T∶U = 275∶219, p = 0.012), while the associations of non-synonymous SNPs Arg30Gln and Pro1371Gln did not reach statistical significance.

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nominally significantno p-value reported

While only these six SNPs were found to be nominally significant in both, the TDT and the case-control analysis, and therefore fulfilled the formal replication criteria, 47 SNPs were significant in only one test, including two more SNPs in the 5p13.1 region (#79, #105), one in NELL1 (#116), and one in the IBD5 region (#191).

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