Geographic variation and localised clustering of congenital anomalies in Great Britain.

Two subtypes showed nominally significant (p < 0.05) heterogeneity over EDs after full adjustment: neural tube defects and specifically spina bifida.

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For example the 5 th –95 th RR range estimated between registers for limb reduction was just 0.76–1.27, but this approached significance at p = 0.097.

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The borderline significant gastroschisis finding is of interest given the increasing trends in prevalence over the last few decades reported elsewhere and rather strong regional differences in prevalence [ 17 - 22 ].

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There was highly significant heterogeneity of all non-chromosomal anomalies across districts and across hospital catchment areas.

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