Results: Before treatment, Pet-1 knockout mice showed a trend toward decreased V E at room air, 3 percent, and 7 percent CO 2 , with statistical significance at 5 percent CO 2 (p <0.05), and an identical V E only at 10 percent CO 2 .
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Under hypoxic conditions, levels of VEGF in cells treated with siRNA to HIF-1α (5.79 ± 0.55), HIF-2α (5.50 ± 1.24), and HIF-1α + -2α (4.24 ± 0.93) were reduced, compared to the hypoxic control (7.27 ± 1.08), yet these effects did not reach statistical significance.