Lack of cor- relation between the absolute values of GSH content and the G2/M-phase by Spearman correlation test may be explained by a larger temporal difference in phasing between GSH and the G2/M-phase as compared with GSH and S-phase. Relationship between S-phase and G2/M phase A highly significant correlation between the S-phase and G2/M-phase was found, suggesting a rapid DNA synthesis rate with cells passing rapidly through the cell cycle.
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DNA cell cycle distribution and glutathione (GSH) content according to circadian stage in bone marrow of cancer patients.
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The remaining 13 patients showed a trend towards higher values of cells in S-phase at daytime as compared to midnight, 14.8 + 1.4% vs. 12.4 ? 1.4%.
This is in accordance with findings in mice (Hazelton & Lang, 1980). The observation may indicate a decreasing resistance of bone marrow cells against free radicals, oxidative injury and detoxification processes with increasing age. Cortisol and cell cyle distribution Although higher S- and G2/M-phase fractions were found during daytime as compared to midnight for all patients, this difference did not reach statistical significance when including patients with an abnormal cortisol pattern, because three of four of these patients also had an inversed circadian varia- tion in S-phase, i.e. higher values at midnight as compared to daytime.