Time trends in prevalence of cervical cytological abnormality in women attending a sexually transmitted diseases clinic and their relationship to trends in sexual activity and specific infections.

0.10) but still highly significant (deviance difference 42.1 on 1 df, P<0.001).

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Adjustment for this positive confounding, however, still left a significant trend to increasing prevalence of herpes virus infection over time; that is, the trend was evident within the separate categories of cytological abnormality which defined the subsample.

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The value of Kappa, 0.26, for 'minor deviations from normal' was probably little affected by the trends in reporting of HPV infection and definite dyskaryosis although this category showed a trend of its own in that more normal smears were considered to show minor deviations from normal on review than conversely.

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