showed a trendp=0.08
Allelic imbalance at the YNZ22 locus (17pl3.3) examined by Southern blotting, demonstrated in 33/63 (52%) informative patients, was significantly associated with disease recurrence (p<0.01, 2df, Cox analysis) and showed a trend towards impaired survival (p=0.08, 2df, Cox analysis) after a mean follow-up of 84 months for survivors.