The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study.

For SNP2, we observed a significant association for the C allele and a strong trend for a RA linkage (AFBAC, RA index cases 66.5% versus controls 56.7%, P = 0.04; TDT, 59.7% of transmission versus 50%, P = 0.06) (Table 2 ).

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The combination of the two samples, authorized by the absence of any significant clinical difference between them, showed a marginally significant association of the C allele (AFBAC, RA index cases 64.8% versus controls 58.2%, P = 0.05; TDT, 56.1% of transmission, P = 0.09) and a significant excess of the C-allele-containing genotype in RA index cases compared with controls (173 RA index cases versus 157 controls, P = 0.02).

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The GRR test showed a trend for an excess of the C-allele-containing genotype in RA index cases compared with controls (90 RA index cases versus 79 controls, P = 0.09) but not for the C/C genotype (Table 5 ).

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