Prognostic impact of proliferation-associated factors MIB1 (Ki-67) and S-phase in node-negative breast cancer.

Other established prognostic factors were not significantly correlated to SPF. Correlations of only borderline significance (P = 0.05) were found between ploidy status and hormone receptor status as well as menopausal status: 39 (87%) of all 45 diploid tumours were steroid hormone receptor positive compared with 30 of 45 (67%) aneuploid tumours.

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All other established prognostic factors (steroid hormone receptor status, grading, menopausal status, lymph vessel invasion, tumour necrosis, tumour size) did not reach statistical significance in the univariate setting.

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In their study, Ki-67 immunostaining was a significant prognostic factor in univariate analysis, whereas S- phase only reached borderline significance.

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