Microsatellite mutations in buccal cells are associated with aging and head and neck carcinoma.

In this comparison, age remained highly significant ( P =0.002, GLM), but smoking (as PY or by category) or case status did not show any effect ( Table 2 ).

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In this analysis, the effect of age was borderline significant ( P =0.067, GLM), while cases had significantly higher levels of D7S1482 mutations than controls ( P =0.017, GLM).

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In this model, only the effect of age was significant ( P =0.021, GLM), whereas cases had higher mutation levels but this did not reach statistical significance ( P =0.104, GLM) ( Table 2 ).

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Although there was a clear trend towards increasing mutation frequency with increasing age, substantial individual differences were also observed.

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