Impact of differential cyclin D1 expression and localisation in prostate cancer.

A positive trend was observed between tumour grade and nuclear p21 Cip1 , but these data did not reach statistical significance ( Figure 5A ).

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Specifically, we showed a trend for increased p21 Cip1 levels with tumour progression and that p21 Cip1 is potentially elevated in tumours with high nuclear cyclin D1 ( Figure 5A and C ).

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The proliferative status of the cytoplasmic cyclin D1 tumours were typically lower than the cyclin D1-negative (7.25±1.34) tumours, although this did not reach statistical significance.

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