Safe liver resection following chemotherapy for colorectal metastases is a matter of timing.

In addition, the mean blood loss was higher in the chemotherapy group (449 ml) compared to the controls (390 ml), but this failed to reach statistical significance ( P =0.067).

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Similarly, there was a striking increase in postoperative mortality (11%) in this group, but again this did not reach statistical significance ( Figure 3 ) possibly reflecting an insufficient number of patients in this subgroup ( n =18) to generate adequate statistical power.

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