Minichromosome maintenance proteins 2 and 5 in non-benign epithelial ovarian tumours: relationship with cell cycle regulators and prognostic implications.

Br J Cancer · 2007 · PMC2360432 · PMID 17940502

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0900

boldest claim

The sentences

a significant trendP =0.0100actually significant

The Cuzick extension of the Wilcoxon's rank sum test confirmed the presence of a significant trend of increasing MCM-2 and MCM-5 expression with increasing tumour stage ( P =0.0100 and 0.0300, respectively).

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failed to reach statistical significanceP =0.0856so close (0.05 < p ≤ 0.1)

However, when poorly differentiated and unspecified cases, which are regarded as high-grade disease, were removed from analysis, the relationship failed to reach statistical significance (Kruskal–Wallis ANOVA, Bonferroni correction, P =0.0856).

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marginal significanceP =0.0900so close (0.05 < p ≤ 0.1)

Survival analysis: population group In univariate analysis, the parameters adversely affecting survival were high grade ( P =0.0330), advanced stage ( P =0.0193), the presence of bulk residual disease ( P =0.0001), increased (⩾20%) MCM-2 expression ( P =0.0004) and increased (⩾25%) MCM-5 expression ( P =0.0100) ( Figure 5A and B ), whereas histologic type attained a marginal significance in this regard ( P =0.0900).

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