UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer.

Br J Cancer · 2004 · PMC2364770 · PMID 15280927

Europe PMC DOI

hedged sentences

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

showed a trendP =0.09so close (0.05 < p ≤ 0.1)

In univariate studies, patients with the UGT1A1 * 28 polymorphism showed a trend to a poorer OS ( P =0.09).

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a significant trendno p-value reported

Furthermore, in a human liver microsome experimental model, a significant trend towards a decrease in SN-38 and bilirrubin glucuronidation rates was found as the number of TA dinucleotide repeats increased (6/6>6/7>7/7) ( Iyer et al , 1999 ).

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