Which endpoints should we use in evaluating the use of novel fluoropyrimidine regimens in colorectal cancer?

However, analysis of the published data by Fisher's Exact test ( Benner, 1999 ; Pazdur et al , 1999 ) showed a trend for increased incidence of grade 3 or 4 diarrhoea with UFT plus LV ( P =0.057), based on a safety population of 406 patients for UFT plus LV and 396 for the Mayo Clinic regimen ( Cunningham and James, 2001 ).

also in 53,322 other papers

A large difference was observed in response rates between the EORTC/AIO (20.5%) and Mayo Clinic regimens (11.5%), but this did not reach statistical significance, most likely because relatively few patients had measurable disease.

also in 111,027 other papers