Histologically normal tissue from patients with polyps/adenoma ( n =15) also showed a trend towards an elevated mean % comet tail DNA compared to normals in most cases (collective comet mean of 50±7.1, n =15), although these results did not reach significance.
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Detection of replicative integrity in small colonic biopsies using the BrdUrd comet assay.
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The sentences
Interestingly, increased BrdUrd comet tails were also found in samples of histologically normal tissue from patients with an abnormal diagnosis, although these data did not reach statistical significance.