Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity.

Br J Cancer · 2004 · PMC2409555 · PMID 14735204

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

a marked trendP =0.055so close (0.05 < p ≤ 0.1)

In contrast, there was a marked trend for a greater FU efficacy in mutated A1298C variants (C/C+A/C) as compared to wt homozygous cell lines (A/A) ( P =0.055 and 0.085 without and with FA supplementation, respectively).

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very close to statistical significanceP =0.055so close (0.05 < p ≤ 0.1)

In ‘physiological-folate’ conditions, FU IC 50 ranged from 0.6 to 25.4 μ M (median 8.4) in the 10 cell lines exhibiting wt A/A 1298 variant, whereas IC 50 were comprised between 0.3 and 7.3 (median 2.9) in the nine cell lines exhibiting mutated A/C or C/C 1298 variants; this difference was very close to statistical significance (Mann–Whitney, P =0.055).

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did not reach statistical significanceno p-value reported

The above observations, which did not reach statistical significance, are depicted in Figure 5 .

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