A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge.

For all strains tested, statistical analysis of data revealed a clear trend of increasing survival probability upon vaccination and vaccination followed by boosting ( P <0.0001).

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All values were considered significant at P <0.05, and highly significant at P <0.001.

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A Cochran-Armitage trend analyses [27] was used to confirm that a significant trend in survival probabilities existed among vaccinated and unboosted, and vaccinated and boosted groups relative to naïve mice in vaccination/challenge studies ( Table 2 ).

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