Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations.

J Med Genet · 2008 · PMC2564860 · PMID 18285424

Europe PMC DOI

hedged sentences

0.0005

closest p · 0.0× alpha

0.0500

boldest claim

The sentences

did not reach statistical significancep = 0.0005actually significant

Although the CGGGG indel did not reach statistical significance independently in all three cohorts, the combined analysis revealed a clear association signal between the CGGGG indel and MS (p = 0.0005), with the longer allele (4×CGGGG) as the risk allele.

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nominally significantp<0.05actually significant

Seven of the 10 polymorphisms showed nominally significant signals of association with MS (p<0.05) ( table 1 ).

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