HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions.

1 D , there is a highly significant difference between hCD2 expression in the Cbx1 −/− animals and the parental genotypes (P < 0.001).

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This showed a trend toward fewer numbers of neurospheres from the Cbx1 −/− cultures compared with Cbx1 +/− and wild-type cultures (P < 0.04; Fig. 4 G ), which is consistent with the E19 pKi-67 staining data ( Fig. 4 F ).

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In this case, the difference between −/− and +/+ and +/− combined is weakly significant (F = 4.63 on 1 and 47 df; P < 0.04); the trend is that fewer neurospheres are generated from Cbx1 −/− brains.

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